Archive for the 'Lung Cancer' Category
A New Genetic Subtype Of Lung Cancer Defined
A report from investigators at the Massachusetts General Hospital (MGH) Cancer Center has defined the role of a recently identified gene abnormality in a deadly form of lung cancer. Tumors driven by rearrangements in the ROS1 gene represent 1 to 2 percent of non-small-cell lung cancers (NSCLC), the leading cause of cancer death in the U.S…
Original post by Wife of a Diabetic
No commentsLung Tumor Gene Test Predicts Surgery Outcomes
An assay which measures the activity of 14 genes in lung cancer tumors can accurately predict who will respond well to surgery and who will probably die within five years, researchers from the University of California, San Francisco, reported in The Lancet…
Original post by Wife of a Diabetic
No commentsMechanism Of Lung-Cancer Drug Resistance Revealed By Study
New research published in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs. The study was led by investigators with the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J…
Original post by Wife of a Diabetic
No commentsStudy Examines Drug Resistance In ALK Positive Lung Cancer
Scientists from the University of Colorado Cancer Center have once again advanced the treatment of a specific kind of lung cancer. The team has documented how anaplastic lymphoma kinase (ALK) positive advanced non-small cell lung cancer (NSCLC) becomes resistant to a drug targeting the abnormal protein in the cancer…
Original post by Wife of a Diabetic
No commentsTB And A Gene Mutation That Causes Lung Cancer Linked
Tuberculosis (TB) has been suspected to increase a person’s risk of lung cancer because the pulmonary inflammation and fibrosis can induce genetic damage. However, direct evidence of specific genetic changes and the disease have not been extensively reported…
Original post by Wife of a Diabetic
No commentsEarly-Stage Non-Small Cell Lung Cancer – Malignancy Gene Signature Found
According to an investigation published in the recent issue of the Journal of the National Cancer Institute, researchers at Moffitt Cancer Center in Tampa, Florida have discovered that a malignancy-risk gene signature created for breast cancer has predictive and prognostic value for individuals suffering with early stage non-small cell lung cancer (NSCLC)…
Original post by Wife of a Diabetic
No commentsIdentification Of Precancer Markers In Airway Epithelium Cells Of Healthy Smokers
Smoking may be associated with the development of molecular features of cancer in the large airway epithelium. In the small airway epithelium, molecular cancerization is associated with development of chronic obstructive pulmonary disease, according to recent data…
Original post by Wife of a Diabetic
No commentsAs Monotherapy And In Combinations, Ganetespib Showed Activity In KRAS-Mutant NSCLC
The investigational drug ganetespib, a synthetic second-generation Hsp90 inhibitor, slowed the growth of cancer cells taken from non-small cell lung cancer tumors with a mutation in the KRAS gene. The drug was even more active when combined with traditional lung cancer treatments and other investigational targeted therapies, according to preclinical study data. David A. Proia, Ph.D…
Original post by Wife of a Diabetic
No commentsCirculating Tumor Cells Analyzed In Patients With Lung Cancer
Researchers have developed a method to analyze circulating tumor cells in the blood of patients with non-small cell lung cancer. This method, which can analyze a sample size as small as three cells, may allow clinicians to track cancer progress and treatments and could help them develop new therapies…
Original post by Wife of a Diabetic
No commentsPotential Genetic Origins, Pathways Of Lung Cancer In Never-Smokers, Mapped By Researchers
Researchers have begun to identify which mutations and pathway changes lead to lung cancer in never-smokers – a first step in developing potential therapeutic targets. Never-smokers (defined as an individual who smoked fewer than 100 cigarettes in his or her lifetime) are estimated to account for 10 percent of lung cancer cases…
Original post by Wife of a Diabetic
No comments