Archive for the 'Lung Cancer' Category
Study Examines Drug Resistance In ALK Positive Lung Cancer
Scientists from the University of Colorado Cancer Center have once again advanced the treatment of a specific kind of lung cancer. The team has documented how anaplastic lymphoma kinase (ALK) positive advanced non-small cell lung cancer (NSCLC) becomes resistant to a drug targeting the abnormal protein in the cancer…
Original post by Wife of a Diabetic
No commentsTB And A Gene Mutation That Causes Lung Cancer Linked
Tuberculosis (TB) has been suspected to increase a person’s risk of lung cancer because the pulmonary inflammation and fibrosis can induce genetic damage. However, direct evidence of specific genetic changes and the disease have not been extensively reported…
Original post by Wife of a Diabetic
No commentsEarly-Stage Non-Small Cell Lung Cancer – Malignancy Gene Signature Found
According to an investigation published in the recent issue of the Journal of the National Cancer Institute, researchers at Moffitt Cancer Center in Tampa, Florida have discovered that a malignancy-risk gene signature created for breast cancer has predictive and prognostic value for individuals suffering with early stage non-small cell lung cancer (NSCLC)…
Original post by Wife of a Diabetic
No commentsIdentification Of Precancer Markers In Airway Epithelium Cells Of Healthy Smokers
Smoking may be associated with the development of molecular features of cancer in the large airway epithelium. In the small airway epithelium, molecular cancerization is associated with development of chronic obstructive pulmonary disease, according to recent data…
Original post by Wife of a Diabetic
No commentsAs Monotherapy And In Combinations, Ganetespib Showed Activity In KRAS-Mutant NSCLC
The investigational drug ganetespib, a synthetic second-generation Hsp90 inhibitor, slowed the growth of cancer cells taken from non-small cell lung cancer tumors with a mutation in the KRAS gene. The drug was even more active when combined with traditional lung cancer treatments and other investigational targeted therapies, according to preclinical study data. David A. Proia, Ph.D…
Original post by Wife of a Diabetic
No commentsCirculating Tumor Cells Analyzed In Patients With Lung Cancer
Researchers have developed a method to analyze circulating tumor cells in the blood of patients with non-small cell lung cancer. This method, which can analyze a sample size as small as three cells, may allow clinicians to track cancer progress and treatments and could help them develop new therapies…
Original post by Wife of a Diabetic
No commentsPotential Genetic Origins, Pathways Of Lung Cancer In Never-Smokers, Mapped By Researchers
Researchers have begun to identify which mutations and pathway changes lead to lung cancer in never-smokers – a first step in developing potential therapeutic targets. Never-smokers (defined as an individual who smoked fewer than 100 cigarettes in his or her lifetime) are estimated to account for 10 percent of lung cancer cases…
Original post by Wife of a Diabetic
No commentsGenetic Composition Of Multicentric Lung Tumors Appears To Be Similar
Multicentric carcinogenesis with the same genetic mutation appears to occur in lung adenocarcinoma, according to data presented at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Biology, Therapy and Personalized Medicine, held Jan. 8-11, 2012…
Original post by Wife of a Diabetic
No commentsLung Cancer Prevention Potential For Estrogen-Targeting Drug Combo
A combination of drugs that target estrogen production significantly reduced the number of tobacco carcinogen-induced lung tumors in mice, according to results from a preclinical study. “Antiestrogens have been shown to prevent breast cancer in some women,” said Jill M. Siegfried, Ph.D…
Original post by Wife of a Diabetic
No commentsSorafenib Effective In Patients With Non-small Cell Lung Cancer, But Low Survival Rates Reported
Sorafenib was effective in patients with non-small cell lung cancer and a KRAS mutation, but survival rates were reportedly “unsatisfactory,” according to data presented at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Biology, Therapy and Personalized Medicine, held Jan. 8-11, 2012…
Original post by Wife of a Diabetic
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